NAD+ or nicotinamide adenine dinucleotide is a vital coenzyme needed by every cell in the body to generate energy. Besides powering every cell and enhancing cellular metabolism, NAD+ helps to keep your body functioning optimally. In recent years, NAD+ has emerged as one of the best ways of fighting to age and improving the quality of life in older people.
Best NAD+ Boosters
Below is a review of the top NAD+ boosters available today.
Elysium is a well-respected firm that aims to promote research and offer customized supplements that enhance human health even in old age. The company has been operating since 2014, and it is primarily known for two products, including the Basis and Index. The Index is a test kit that measures your exact biological age, while Basis is their top-quality supplement designed to improve your aging process.
Elysium Basis contains two key ingredients, nicotinamide riboside, and pterostilbene. Each pill helps boost your cell metabolism and the cells’ ability to rejuvenate and repair themselves. These two critical areas typically get impaired with age, so people regard this product as an efficient anti-aging solution. Elysium recommends taking two pills every day, thus delivering at least 500mg NR and 100mg pterostilbene. Interested users can expect to pay at least $60 per bottle of Elysium Basis.
NR Chloride Powder
The NR Chloride Powder from Science.bio is also classified as a high-strength NR supplement. The powder is easy to use, and it comes in small 10 gram jars for less than $30. The advantage of having NAD+ supplements in powder form is that you can add the powder to your favorite health drinks like pre-workout mixes and enjoy the numerous health benefits. Most importantly, Science.bio is known for testing all their products and providing access to their lab results. This manufacturer adheres to strict production criteria and delivers high-quality NAD+ supplements without any artificial additives.
If you want 98% pure nicotinamide mononucleotide, then you should check out LiftMode NMN. NMN is similar to niacin and NR since it works as an NAD+ precursor and can help to boost NAD+ production. Research shows that NMN may enhance insulin production while improving glucose tolerance in the body. In addition, NMN increases the availability of NAD+ in the brain to improve mental health and cognitive function. LiftMode NMN is available in a resealable and transparent 5-gram jar. Each product comes with a COA test of the specific batch along with a handy measuring scoop. Each serving provides 100mg of pure NMN, and the bottle goes for $67.68.
The San Diego-based Cymbiotika company uses top-notch bioavailable absorption technologies and high-quality sources of organic nutrients across all its products. The Cymbiotika NMN combines all the benefits associated with NMN supplementation with antioxidants and polyphenols. The result is a product that can effectively enhance NAD levels across the body. This supplement works at a cellular level to help with energy production, anti-aging, and other benefits.
Like other Cymbiotika supplements, the Cymbiotika NMN does not contain any preservatives, additives, artificial flavors, or GMOs. It is also vegan, soy, gluten, and lactose-friendly. Pricing for this supplement starts at around $77.
Alive By Science
One of the biggest producers of NAD+ supplements is Alive By Science. The company has been in operation since 2017, and they have been creating innovations with new delivery mechanisms and products. The issue with most NMN pills is that they get wasted or degraded by acid in the gut. Alive By Science has tackled this issue by increasing the absorption rate of its sublingual capsules. The use of sublingual delivery helps to bypass NAMT, an enzyme that breaks down NMN. Even though these pills only deliver 125mg NMN, they offer far better absorption rates than other competitors.
Alive By Science offers numerous types of NMN such as sublingual, intranasal, transdermal, and liposomal products. Consumers also have the option of either buying the capsules or the powder form. Since the NAD+ sector has been booming and reduced manufacturing costs, this company has significantly slashed its supplement prices. Interested buyers can get Alive By Science supplements for less than $100.
Unlike other supplements that only contain trace amounts of NR, RiboGEN offers 300mg NR, which is significant. The manufacturers of this supplement say that they are the only firm offering the same NR purity and concentration used in clinical studies and medical research. The RiboGEN NR is a crucial precursor to the production of NAD, which means it gives the body the right ingredients to create NAD and ensure better NAD+ levels. RiboGEN offers a high concentration of NR of around 99.5% and 0.5% NAM, which makes it a potent NAD+ supplement linked to multiple benefits. Nevertheless, the high potency is reflected in the over $300 price tag, making RiboGEN one of the pricier options featured here.
Everything about Toniq NMN stands out, particularly regarding both the ingredient composition and the packaging. The premium packaging quality is a welcome addition since most supplements tend to look quite dull. Besides the eye-catching design, Toniq NMN offers a highly concentrated and pure form of NMN to ensure you have the necessary precursors to enhance your NAD+ production. Consumers can quickly get their hands on Toniq NMN as it is one of the cost-effective options featured here, with one bottle costing less than $50. Each capsule of this supplement contains 99% nicotinamide mononucleotide that helps increase NAD+ generation in your body to receive a range of positive benefits.
NAD+ Cell Regenerator
Life Extension is a well-known nutritional brand that was amongst the premier companies to market the health benefits of niagen and resveratrol. Both of these ingredients are now powerful nutrients that help in promoting longevity and cellular health. The NAD+ Cell Regenerator contains beneficial phytonutrients like quercetin, trans-pterostilbene, and fisetin. It is also non-GMO and gluten-free. The vegetarian-friendly capsules are available in either 300mg or 100mg jars, ranging between $20 and $50 for a single bottle.
HPN NAD3 Booster
NAD3 NAD+ Booster from HPN supplements seeks to offer users a way to deal with aging and a host of other health issues. Unlike other NAD+ supplements on this list that use NMN or NR to improve NAD+ levels in the body, this product uses a customized patent-pending blend. The proprietary blend contains wasabi, copper nicotinic acid, and theacrine that all combine to boost your NAD+ levels. The primary benefits to expect from this NAD+ booster are lower cellular inflammation, detoxification, improved mitochondrial function, and other health benefits. Prices of NAD3 start at around $60, which makes it one of the more affordable NAD+ supplements featured on this compilation.
Liposomal NAD+ Gold
Liposomal NAD+ Gold by QuickSilver Scientific uses liposomal technology to promote more excellent absorption into the targeted cells. This product uses the latest liposomal delivery to ensure the tiny NAD+ particles are absorbed into the cells and bloodstream. The unique aspect of this delivery technology is that it mimics your body’s in-built NMN transportation system to guarantee better benefits with less wastage.
While the Liposomal NAD+ Gold may have a low dose of NMN, the supplement redeems itself by including a beneficial blend of multiple NAD+ enhancing ingredients. Some of the key ingredients include vitamin B12, quercetin, vitamin B2, and TMG. The supplement can increase your NAD levels and activate the sirtuins protein family that helps to fight aging symptoms.
Designed by ChromaDex scientists, Tru Niagen offers a simple way to boost the NAD+ levels in your body. This supplement delivers pure nicotinamide riboside chloride that the body will convert to NAD once ingested. The NR also enhances the volume of NAD+ in the user’s body. The company offers several purchase options depending on your dosage needs. You can get the 300mg one-month monthly package at $47 or the two-month 150g package at $87.95. Consumers can also save on purchase costs by using promo codes or subscription packages available on the official site.
NAD+ Boosters Delivery Considerations
Here are the main options when it comes to NAD+ availability and delivery:
One of the most used and cheapest forms of NMN supplementation is through powder form. The most affordable products available today fall in this category. However, it is also one of the low bioavailable forms of NMN. That is because your stomach acid will often degrade the unprotected NR and NMN into nicotinamide or NAM before it reaches the critical organs and tissues. Excess NAM in the body has adverse health consequences like inhibiting sirtuins, an essential protein family that contributes to longevity and cellular health. That means it may not be helpful to consume larger doses of NMN powder when countering the issue of low bioavailability.
The sublingual NMN delivery is much more costly than general powders, but it offers significantly better absorption. It goes below the tongue and bypasses your liver before diffusing quickly into the blood. Since more significant quantities of sublingual NMN content reaches your blood, most users report feeling a substantial surge of energy.
The newest upcoming method of NMN consumption is intranasal. This method is unique since it bypasses your blood-brain barrier and directly enhances the levels of NAD+ in your brain. In addition, nasal administration typically requires lower doses, and it has a better effect on your brain. However, most intranasal NMN supplements are also quite costly due to the limited supply of such products.
The primary benefit of liposomal supplements is that they offer better and more efficient absorption rates. Most importantly, these supplements do not break down or get digested in your gut. Most of the top NAD+ boosters use the liposomal delivery method to guarantee sustained release and effective absorption. A liposome is a small fatty shell that resembles the normal cell membrane. The use of liposomes prevents digestion by acid in the stomach and promotes better use across the body. Many supplement manufacturers have proclaimed major liposomal breakthroughs in their products while advertising high bioavailability. Liposomal NMN is highly beneficial since liposomes offer better value as they only require a small dose.
Scientific evidence for NAD+ benefits
Here are some of the suggested health benefits of consuming NAD+ along with the supporting scientific research:
Muscle function improvement
Research shows that NR can restore muscle mass and preserve NAD levels in muscles while also improving the exercise and performance capacity in specific animals. Mitochondrial myopathy refers to a condition where the mitochondria are damaged, which leads to muscle weakness. Scientists found that offering NR supplementation to mice helped inhibit myopathy’s progression by eliminating mitochondrial abnormalities. The NR supplementation reduced the consumption of NAD+, which enhanced mitochondrial function and energy production.
Even though the antioxidant effects of NR are yet to be tested on humans, there are promising results in other animal studies. For instance, one study found that NR consumption lowered the adverse effects experienced in mice due to oxidative stress. Having low NAD+ production levels are typically hypothesized to result in DNA damage. However, NR supplementation enhances the NAD+ levels in the body, which helps to prevent oxidative damage, tumor progression, and DNA damage.
Alleviating diabetes symptoms
Data shows that NR supplementation may help prediabetic mice by improving glucose tolerance, reducing liver damage, and weight management. NR reduces blood glucose levels and protects against nerve issues associated with diabetes. Nevertheless, more studies are necessary to understand the impacts of NR and NAD+ consumption on humans with diabetes.
Improving brain health
Scientists are also exploring the beneficial effects of NAD metabolism in supporting brain health. It is believed that NR enhances brain health and nerve cells by activating specific pathways while inhibiting axonal degeneration. In addition, NR supplementation slowed down Alzheimer’s diseases and increased cognitive function in mice when administered for at least three months.
Improving liver health
A research team recently studied how NR administration increased the availability of NAD in specific animals. The researchers suggest that the properties of NAD may improve liver health. During the study, the researchers observed that the NR had prevented fat accumulation, enhanced insulin sensitivity, reduced oxidative stress, and prevented inflammation in mice’s liver.
Oral NR supplementation after significant noise exposure helped to prevent hearing loss and other ear issues in mice. The NR prevented nerve cell degeneration, which typically occurs after exposure to loud noises. The researchers noted that NR’s effects on hearing problems in humans still require more tests.
Anti Aging effects
One of the main reasons NAD+ boosters are in high demand is because they are primarily marketed as the best anti-aging supplements. However, the reality is that there is insufficient clinical data to show that NR offers significant longevity-enhancing effects. This is a widely researched topic, and many scientists believe that NR could have anti-aging properties since it boosts the availability of NAD+ inside the body. NAD can help to increase longevity by reprogramming and rejuvenating dysfunctional cells. Some studies cite a specific animal study where NR supported the production of prohibitin proteins and enhanced the mitochondrial response to rejuvenate stem cells and stop rapid aging in old mice.
Enhancing mitochondrial health
Researchers believe that the mitochondria and nucleus can metabolize NR. NR increases the mitochondrial and nuclear levels of NAD+, which activates mitochondrial SIRT3 and nuclear SIRT1 pathways.
Even though most of the NAD+ studies mentioned above have involved using mice as test subjects rather than human participants, there have also been numerous human trials. For instance, during one study, the scientists found that NR supplements helped significantly improve NAD+ in several healthy adults. Likewise, a different study concluded that NR supplements successfully enhanced the levels of ADPR and NAD+ in the body. Nevertheless, while more research is required to certify the claims mentioned above, growing evidence shows that these supplements are beneficial to your overall health. In addition, besides the supplements discussed above, there are other natural sources of NR, including whey protein, milk, and yeast, among others.
How to boost your NAD levels naturally
Listed below are some of the practical ways you can use to boost your NAD levels at home:
Fasting typically involves switching to a low-calorie intake diet or stopping eating entirely for a specific duration. Fasting is highly beneficial to your health since it can boost your NAD levels and increase the availability of sirtuins, which are unique proteins that help slow down aging. Even though fasting may be effective for boosting NAD+ levels, you should be careful to avoid sudden reductions in food intake. The best approach is to use an intermittent fasting plan or switch to a low-carbohydrate keto diet to offer similar results.
NR dietary supplements
The other notable source of good quality NR is from dietary supplements, like the ones featured above. Research shows that the body uses NR to create NAD+. This important discovery has led to an influx of NR supplements in the market. Various studies show that daily consumption of NR supplements can help enhance the production of NAD + inside the body.
Performing physical activities such as simple exercises can also help to increase NAD+ levels. Every time you exercise, your body requires energy to sustain your performance, derived from NAD+. Generally, that means that the workout forces your muscles to generate more mitochondria, which naturally enhances NAD+ levels in your system.
Reduce sunlight exposure
Researchers have found that excessive exposure to direct sunlight may deplete your body of its NAD+ levels. That is because your body uses the NAD+ when performing cell repair due to the damage caused by direct exposure to harmful UV rays. If you find that direct exposure to the sun is inevitable, then you must wear sunscreen, sunblock, or a pair of sunglasses to protect your skin.
Reduce alcohol intake
NAD+ is critical for maintaining and optimizing the metabolic processes within your body. The consumption of alcohol often inhibits these essential processes and significantly reduces the efficiency of NAD. Hence, the solution is to minimize or avoid excessive alcohol consumption.
Foods that enhance NAD+ levels
Some foods can also help you to maintain or increase your NAD+ levels, and they include the following:
- Dairy milk: Milk is an excellent source of RM, and it can give you significant amounts of NAD+, allowing you to get healthier and younger.
- Fish: Another reason to enjoy various fish varieties like salmon, sardines, and tuna is potent NAD+ sources.
- Mushrooms: Most people consume mushrooms as part of their regular diets. Certain varieties of mushrooms, such as cremini mushrooms, help in naturally improving NAD levels throughout your body.
- Yeast: There are multiple uses of yeast, including as an ingredient in the production of bread. Yeast contains RN or riboside nicotinamide, which is one of the essential NAD precursors.
- Green vegetables: Vegetables contain a broad range of nutrients that help improve your health in various ways. Researchers have recently discovered that the consumption of green vegetables like peas, asparagus, and many others could increase NAD+ levels.
- Whole grains: Vitamin B3 is also a potent RN source. However, when most food items, grains, or vegetables are processed or cooked, they tend to lose most of their nutritional content. Hence, it is advisable to consume organic and unprocessed whole grains to ensure sufficient amounts of RN in your system.
What are the effects of low NAD+ levels?
As mentioned above, NAD+ is present in all the cells in your body. It is necessary for effective energy transfer between foods and tissues. This coenzyme is also helpful in turning off specific aging genes, thus helping to regulate aging.
When you have low NAD+ levels, it means your mitochondrial functions at the cellular level will be affected. That means your cells will have less energy since fewer mitochondria and fewer ATP molecules are being produced. This cycle of low NAD+ levels is responsible for most of the signs of aging in people.
The reduction of NAD+ with age causes significant defects and inefficiencies in both the gene- and energy-related functions to build up. These defects accumulate and gradually cause various disorders, including aging. Here are the critical consequences to expect from low NAD+ levels:
- It causes rain neurodegeneration which causes various health issues like Alzheimer’s disease or lack of cognitive function.
- Vascular inflammation may also occur, resulting in damage to your blood vessels, leading to heart attack or stroke.
- Low NAD+ causes increased fat storage within your liver, and it can result in NAFLD disease.
- It causes increased fat deposits within white adipose tissues, the primary storage type in risky belly fat.
- It increases insulin resistance and prevents your cells from effectively extracting glucose from the blood. It causes high levels of blood sugar and directly leads to low metabolism.
- Lack of NAD+ also affects your muscle strength and causes fatty muscle infiltration and excessive fatigue. That is because insufficient NAD+ deprives your muscles of their essential energy source.
To avoid all the degenerative processes mentioned above, it is vital to take proper steps to increase your NAD+ levels. For instance, taking the supplements shown above can help increase cellular levels of NAD+ and reverse most of the issues shown above. If you can’t engage in major calorie-limiting diets, the best option is to use dietary supplements to correct the mitochondrial dysfunction and keep your cells performing optimally.
What are the side effects of NAD+ boosters?
NAD+ boosters are usually well tolerated by most adults. In addition, there are no severe adverse reactions that were reported during clinical trials for people taking nicotinamide riboside doses. Hence, you can safely consume 1,000mg NR two times each day for an extended period without experiencing any adverse reactions. In addition, like other dietary supplements available today, NAD+ supplements contain ingredients and doses that are safe to consume when using the recommended daily consumption instructions.
Nevertheless, individuals with chronic health conditions and also those who are pregnant or breastfeeding should consult their healthcare provider before using any dietary supplement. Furthermore, most NAD+ boosters are designed for adults and should be kept away from kids.
How to choose the best NAD+ booster
All NAD+ supplements claim to improve your NAD+ levels and provide numerous positive health effects like improving muscle function and fighting aging, among others. Here are the essential ranking considerations when choosing an effective NAD+ product:
Clinical trials and scientific proof of NAD+ boosters
Most of the premium NAD+ supplements spend lots of money and time in research and development to produce scientifically-backed products. Companies that invest in clinical trials and other studies will generally create more effective NAD+ boosters.
The ingredient dosage is another essential factor to keep in mind when selecting NAD+ products. The best option is to go with products that offer more potent doses of NMN or NR as they will work more effectively.
Some low-cost NAD+ supplements often feature proprietary formulas, and they also hide their exact ingredient composition. The ideal choice is to go with NAD+ brands with simple ingredient labels to guarantee what you want in an NAD+ product.
Most NAD+ supplements contain either NMN or NR as the main precursors to boosting NAD+ levels. Hence, you should ensure that the NAD+ supplement you pick comes with either of these two ingredients and in the purest version available.
Research shows that combining various complementary ingredients with NMN and NR could significantly enhance your NAD+ levels. That is why most of the NAD+ products featured above contain additional ingredients like resveratrol, turmeric, and other beneficial compounds. Nevertheless, ensure that the manufacturer has not added any artificial additives.
Expected health benefits
The ideal NAD+ supplement does not exaggerate its health benefits. Avoid products that claim to reverse decades of aging or those that promote rapid weight loss. Good quality NAD+ products will often have more honest expected health benefits.
All the brands featured above are well recognized and known for their impressive NAD+ supplements. The advantage of buying from well-established brands is that you can expect better quality and more effective dietary supplements.
Cost and value
The prices of NAD+ supplements will vary depending on the manufacturer. Some supplements are priced below $50, while others require over $300 per bottle. Ensure you are getting a good quality product regardless of the price.
What is the recommended dosage for NAD+ boosters?
Many of the NAD+ supplements featured in this compilation deliver an average dose of 300mg NR or the equivalent NMN dosage. Numerous studies have shown that this high dosage is critical for improving NAD+ concentrations in your body. In addition, studies recommend that anywhere between 100mg to 1,000mg NR is sufficient for enhancing NAD+ inside the body. Generally, you should buy an NAD+ supplement that offers at least 300mg NR in each serving to guarantee better NAD+ enhancing effects.
Best NAD+ Boosters Conclusion
NAD+ has a vital link to the general quality of life and health. First, it converts food nutrients into ATP and helps to create cellular energy. Secondly, it works together with specific proteins to perform various biological processes like DNA repair, regulation of energy metabolism, gene expression, mitochondrial function, optimizing chromosomal integrity, and other core processes.
Regular supplementation with NAD+ boosters can also prevent fast or premature aging. These supplements are generally characterized as safe, and they don’t have any bad adverse reactions. Additionally, growing research continues to validate some of the NAD+ health benefits. If you want to try out NAD+ boosters, then pick any of the products mentioned above.
The manufacturer links provided in this NAD+ booster review may result in a commission if you choose to purchase the supplement suggested at no extra cost to you. These funds contribute to our editorial team and research. Please take note that we only recommend top-quality products from trustworthy manufacturers.
Please note that any guidelines, advice, or recommendations given here should not be considered a substitute for advice from a professional medical practitioner. Before purchasing any products on our list, consult with your doctor, especially if you suffer from other medical conditions or have questions about the supplements discussed in this review. Each individual may experience different effects, as the benefits of the NAD+ booster supplements are not FDA-approved (Food and Drug Administration). The FDA has not verified the efficacy of NAD+ boosters. These products are not intended to treat, diagnose, prevent or cure any disease.