Best Nootropic Supplements That Work: The Most Effective Brain Boosters

Got an important exam coming up? Or maybe you are feeling stuck with that big project while the deadline looms over your head? We have all been there when your brain is all fuzzy, and you cannot brainstorm an idea or focus on anything.

If that’s what you are feeling, it’s time you gave natural nootropics a shot!

Nootropics are smart drugs or supplements made from all-natural ingredients that protect and enhance brain function. These “smart drugs” are engineered to improve cognitive function and increase mental performance.

Whether you’re a business tycoon, a football coach, a school teacher, or a stay-at-home mom of three, all you need is little help with improving your brain function from time to time. The truth is, you can’t get all the nutrients from food; taking brain supplements increases blood flow to your brain and makes it sharper. Nootropics sharpen your foggy brain, so you can concentrate better and give your 100% every single time.

No matter what age group you belong to, these natural brain supplements will help you achieve tremendous success in every area of your life. Natural nootropics not only boost memory and focus but also improve your creativity, motivation, Mood, and overall health.

However, not all nootropic stacks are created equal – some work miracles while others fail.

So if you have decided to enhance your memory and brain function, you need nootropics that are legit and do the job well.

Here is our highly-researched and vetted list of the 33 best nootropics supplements you can get in 2022.

The Top 33 Best Nootropics of 2022

Our list consists of only science-backed nootropic supplements that will unleash your brain’s full potential. Our research team has selected only the best nootropic supplements on the market based on their ingredients, pricing, featured benefits, and reviews.

Mind Lab Pro: Mind Lab Pro can improve brain function and memory retention, according to an independent research
Ageless Brain: 11 high-quality ingredients support cognitive function and brain cells
Nuzena Neuro Focus +: Using this formula, you can optimize brain function in no time
SANE Vitaae: Brain energy utilization is increased by 90% using the Brain Trick
Nootrogen: This nootropic formula contains 100% natural ingredients that improve cognitive function and mental performance
Performance Lab Mind: Performance Lab Mind has been described as an advanced nootropic supplement
NooBru: An excellent cognitive enhancer for maximizing brain potential and mental performance
Hunter Focus: Nootropic supplements can help you gain better focus faster
Synapse XT: The nootropic stack promotes a healthy brain and better hearing
Vital Plan Brain Boost: It was developed by physicians to improve mental health and promote brain cell regeneration
NaturalCell NeuroActiv6: Improves cognitive function and yields faster results
Natural Stacks NeuroFuel: It takes just 30 minutes for this original CILTEP® blend to begin working to promote brain health
Onnit Alpha Brain: Alpha Brain provides daily cognitive support through carefully selected ingredients
NooCube: Ingredients in this product boost brain function in a comprehensive manner
Qualia Mind: It is an advanced combination of natural ingredients that boosts brainpower
UpWellness Mind & Mood: It is one of the best nootropic supplements for stress and anxiety
PureEssence BrainEssence: It contains the world’s most potent nootropic nutrients
Amy Myers MD NeuroLive: Formulated to support the brain cells and functions with seven micronutrients
Brain C-13: Doctors formulate this nootropic supplement to improve brain function with herbs
Elm & Rye Nootropics: Enhance cognitive function and boost mental energy levels with this preoperative blend
Neuro: These functional gums will significantly benefit your mental energy and mental performance
PureHealth Research Ageless Brain: This nootropic supplement is unique and premium
Cymbiotika Golden Mind: A comprehensive formula of advanced brain nutrients for healthy brain cells production
CogniBiotics: Improve your gut and brain health with a new probiotic formula
ProMind Complex: With its formula, this product promotes six distinct techniques for enhancing memory retention
Oweli Neuro: You can boost your brainpower by 100 times with this formula
Youthful Brain: Formulated by Doctor Sam Walters, an experienced physician
Brain Pill: Brain Pill is described as a secret treatment for poor brain function
OptiMind: With its premium ingredients, it improves concentration and energy levels
MemoSurge: It is among the most effective brain supplements for improving mental function
ReMind Solution: Enhancer of cognitive performance that supports six different performance indicators
Memo Defend: A pure and effective ‘Work Of Art’ for mental clarity and enhanced brain function
Memory Hack: Quickly boost your brainpower with this natural brain booster

Mind Lab Pro

Product Description
Company: Opti-Nutra
Working Components: Mind Lab Pro contains potent ingredients such as citicoline, Rhodiola Rosea extract, phosphatidylserine, lion’s mane mushroom, and Maritime Pine Bark Extract for brain cell development and improved mental health
Quantity Delivered: 60 capsules in one pack of Mind Lab Pro
Serving Size: Two capsules
Assurance: A complete satisfaction guarantee
Mind Lab Pro Retails for $69

Is it your first time trying a nootropic? Look no further than the Mind Lab Pro!

Mind Lab Pro is the most well-known brain supplement on the internet and has made rounds amongst nootropic enthusiasts for years.

Regardless of the price, Mind Lab Pro is one of the best nootropic supplements. It is a great starting point for those just starting on their nootropic journey. Each capsule of Mind Lab Pro comes packed with NutriGenesis vitamins that maximize bioavailability and absorption. So, if you’re looking for a nootropic that has all the good stuff and no fillers, Mind Lab Pro is a must-try.

Ageless Brain

Product Description
Company: Organixx
Working Components: Apart from common Nootropic substances like Bacopa monnieri, it’s made from unique ingredients such as Camu Camu, cat’s claw, dragon’s blood, and cacao. But if you’re allergic to cinnamon, you might want to skip this one
Quantity Delivered: 60 capsules
Serving Size: Two pills
Assurance: 365-day money-back guarantee
Ageless Brain Retails for $55

This blend is perfect for those nootropic fans who want to try something new and exciting. Ageless Brain by Organixx is a brain booster the likes of which you can’t easily find on the market. The formula can enhance new brain cell production, improve brain function, mental health, and avoid cognitive decline by regulating brain chemicals.

Despite the need for more research to verify the benefits of some of its ingredients, the Ageless Brain has been shown to support healthy cognition in numerous ways using its one-of-a-kind active ingredients.

Nuzena Neuro Focus +

Product Description
Company: Nuzena
Working Components: In every 692mg of the Nootropic, you get glutamic acid, Maritime Pine Bark Extract, bilberry fruit extract, DMAE bitartrate, and amino acids to improve focus and mental health
Quantity Delivered: 60 pills
Serving Size: Two capsules
Assurance: Not any
Nuzena Neuro Focus + Retails for $30

A nootropic formula that’s highly rated and comes packaged in an attractive bottle – Neuro Focus + is full of many vitamins and minerals in every gram. It’s made from 100% natural ingredients that support healthy brain function, mental recall, brain cell repair, concentration, and optimize brain health overall.

The best thing about Neuro Focus + is that it is locally made. Hence it is made from the best quality ingredients.

SANE Vitaae

Product Description
Company: SANESolution
Working Components: Each capsule’s product gives you a good dose of vitamin D, omega-3 fatty acids (amino acids), folate, L-carnitine, and many other vital nutrients
Quantity Delivered: 45 pills
Serving Size: Three capsules
Assurance: One-year money-back guarantee
SANE Vitaae Retails at $47

The next on our list of best nootropic supplements is Vitaae, developed by the infamous SANE laboratories. The formula promises to mend what they call the “leaky brain” that causes you to have a slower metabolism, lack of focus, memory loss, anxiety, and even depression.

The Nootropic consists of patented CognizinTM, which supports brain cellular synthesis and boosts brain energy levels. It can also improve focus, new brain cell growth, and concentration. It is the only multi-nutrient formulation proven to improve mood and brain function according to the brand, which aids in alleviating symptoms of depression.


Product Description
Company: Vita Balance
Working Components: Nootrogen has some lesser-known ingredients such as L-tyrosine, glutamic acid, and DMAE that can improve blood flow, mental acuity and provide multiple cognitive benefits
Quantity Delivered: 60 pills
Serving Size: Two pills
Assurance: Not any
Nootrogen price Retails at $30

The makers of Nootrogen, like others on this list, promise that the supplement will certainly give your brain a boost when taken regularly. At only $30 a bottle, Nootrogen is on the budget-friendly side like some other best nootropic supplements on our list. Thanks to the lower price, you can easily repurchase the capsules and ensure your brain is working at its best at all times.

Each serving has a 642mg proprietary formula that contains herbal extracts and amino acids that combine to support cognition in many different ways. Taking just two capsules every day will help you achieve better mental performance, brain energy, and mental benefits.

Performance Lab Mind

Product Description
Company: Performance Lab
Working Components: Performance Lab Mind includes potent, active ingredients like L-tyrosine, phosphatidylserine, maritime pine bark extract, and citicoline that pack a punch in a capsule
Quantity Delivered: 30 nutricaps
Serving Size: One to two nutricaps
Assurance: 30-day money-back guarantee
Mind Price Retails at $69

Mind by the Performance Lab is a nootropic supplement with simple packaging yet a highly effective formula.

The Performance Lab Mind provides your body a mix of vital nutrients such as vitamins, antioxidants, minerals, etc., that increase your brainpower with a single dose. As a result of taking the Performance Lab Mind daily, you may be able to boost your brain’s energy by up to 13.6%, according to their website. It promises to offer various long-term brain health benefits. Performance Lab Mind can improve focus, memory retention, increase motivation, and even promote recovery after extreme mental fatigue.


Product Description
Company: NooBru
Working Components: Noobru is fortified with alpha vitamin B5, GPC, L-theanine (amino acid), Huperzine A, ashwagandha, and choline bitartrate to offer various mental benefits
Quantity Delivered: 20 servings
Serving Size: Once scoop
Assurance: 100% satisfaction guarantee
NooBru Price Retails at $55

It certainly won’t be wrong if we say that Noobru is an elite brand of nootropics. This product is targeted toward athletes, students, and those who work in competitive fields.

The nootropic stack provides long-term brain health benefits. Also, it can boost memory retention power, cognitive health, and mental performance by fighting cognitive decline and mental fatigue.

In contrast to other nootropic supplements, NooBru discloses all ingredients and dosages right there on the package. There are no hidden fillers in NooBru, and all elements are incorporated at potent dosages.

Hunter Focus

Product Description
Company: Roar Ambition
Working Components: The critical ingredients of Hunter Focus are Bacopa monnieri, phosphatidylserine, Maritime Pine Bark Extract, and passionflower. You can also find these active ingredients in the other nootropic supplements mentioned on our list
Quantity Delivered: 120 pills
Serving Size: Four capsules
Assurance: Not any
Hunter Focus Price Retails at $60

Want to gain an edge over your competition and overcome the various hurdles in your life?

Hunter Focus is the correct nootropic blend for you!

Roar Ambition’s Hunter Focus is a nootropic supplement designed to give you a competitive edge. With every serving of Hunter Focus, this all-natural, high-quality formula can boost your thinking power, improve cognitive function and boost mental performance.

In addition to marketing itself as a smart solution to cognitive exhaustion, Hunter Focus also features one of the best-looking packaging bottles on the market. Furthermore, the company does a commendable job at disclosing all dosages upfront.

Synapse XT

Product Description
Company: NA
Working Components: It uses a mix of natural herbs, minerals, plant-based ingredients, and multiple vitamins to strengthen your brain performance
Quantity Delivered: 60 capsules
Serving Size: Two capsules
Assurance: Not any
Synapse XT Retails at $69

Synapse XT is a nootropic supplement that improves your senses, primarily hearing. Hence, if you’re an older gentleman or lady suffering from hearing issues, Synapse XT might be the Nootropic you need.

The West Jordan, Utah-made nootropic supplement is more expensive than other blends on our list, with similar ingredients. That being said, it may be just what a person needs to support their cognitive health and proper hearing.

Vital Plan Brain Boost

Product Description
Company: Vital Plan
Working Components: Each capsule of the supplement is full of fantastic nootropic ingredients like Ginkgo Biloba, Bacopa monnieri, cat’s claw extract, lion’s mane mushroom, and ashwagandha, making it a powerful health supplement
Quantity Delivered: 120 capsules
Serving Size: Four capsules
Assurance: 90-day money-back guarantee
Brain Boost Retails at $48

Vital Plan’s Brain Boost offers a lot of value at a relatively low price. At $48 a bottle, the company claims that Brain Boost encourages better memory retention, brain focus, clarity, energy, immunity, lowers stress, and slow cognitive decline. It even aids in improving the health of your gut by letting the naturally occurring microbes flourish.

Created by Dr. Bill Rawls MD, Brain Boost has potent dosages and no proprietary formulas, making it one of the best nootropic stacks of 2022.

NaturalCell NeuroActiv6

Product Description
Company: NaturalCell
Working Components: It contains a range of natural nootropics, including ashwagandha, turmeric, coffee fruit extract, citicoline, and B vitamins, to slow cognitive decline and enhance overall cognitive performance
Quantity Delivered: 30 servings
Serving Size: One scoop
Assurance: 60-days money-back guarantee
NeuroActiv6 Retails at $46 a month

Want to try an easy way to boost brainpower and cognitive performance?

NeuroActiv6 is the right choice for you!

With one scoop of NeuroActiv6, you can set yourself up for long-term benefits like a boost in brain energy, oxidative stress resistance, healthy cortisol levels, BDNF levels, and neural connections, to name just a few.

The supercharged nootropic powder formula NeuroActiv6 from NaturalCell supports cognitive health, improves concentration, and boosts mental clarity.

Natural Stacks NeuroFuel

Product Description
Company: Natural Stacks
Working Components: The nootropic stacks have substantial doses of a smaller number of ingredients, such as artichoke leaf extract, acetyl L-carnitine (amino acid), and L-phenylaniline, to provide more significant benefits than the other formulas listed here
Quantity Delivered: 45 pills
Serving Size: Three pills
Assurance: Money back guarantee of 30 days
NeuroFuel Retails at $30

Nootropic supplement NeurolFuel helps with mental clarity, memory retention, and cognitive functions. Despite NeuroFuel’s similarities to other nootropics we’ve recommended here, one crucial detail that differentiates it is that all of its natural nootropic ingredients and sources are traceable via blockchain, making it our only “open-source” Nootropic.

Onnit Alpha Brain

Product Description
Company: Onnit
Working Components: Among Alpha Brain’s ingredients are Bacopa monnieri, oat straw, Huperzia Serrata, cat’s claw, and others that have been found to improve cognitive functions
Quantity Delivered: 90 capsules
Serving Size: Two capsules
Assurance: Complete satisfaction guarantee
Onnit Alpha Brain Retails at $35

The best-known nootropic supplement sold online today is Onnit Alpha Brain. Alpha Brain, promoted by American podcast host and celebrity Joe Rogan, facilitates memory, concentration, and daily cognitive function. Having sold more than one million bottles of Alpha Brain, Onnit is a household name for a reason.

Alpha Brain’s high-quality formula gives you the upper hand over your challenges. The high costs of clinical trials prevent many brain supplements companies from investing in them. However, being clinically tested and peer-reviewed, Onnit Alpha Brain is one of the best nootropics on our list that works.

NooCube Brain Productivity

Product Description
Company: Wolfson Brands (UK) Limited
Working Components: The active ingredients in NooCube’s supplement to aid in increasing your brain health include Alpha GPC, cat’s claw extract, Bacopa monnieri, and Huperzine A
Quantity Delivered: 60 capsules
Serving Size: Two capsules
Assurance: 60-day money-back guarantee
NooCube Brain Productivity Retails at $60

A nootropic supplement formulated by leading neuroscientists, NooCube Brain Productivity, is unlike many other brain boosters online. The NooCube nootropic contains zero caffeine. So, rather than giving your brain a buzz with caffeine, it relies on herbal and other plant extracts to source active ingredients to target brain pathways and offer cognitive benefits.

While it’s on the pricier side, it delivers value for money with good quality ingredients and effective dosages, which is why we added it to our list of best nootropic supplements.

Qualia Mind

Product Description
Company: Neurohacker Collective
Working Components: The nootropic stack has natural nootropic ingredients like Bacopa Monnieri, Rhodiola Rosea, N-Acetyl L-Tyrosine, Taurine, DL-Phenylalanine, and Uridine-5
Quantity Delivered: 154 pills
Serving Size: Two to three pills
Assurance: 100-day money-back guarantee
Qualia Mind Retails at $59

The brain-enhancing nootropic supplement Qualia Mind from Neurohacker Collective lives up to its hype with remarkable active effects. With 28 brain health ingredients, Qualia Mind supports focus, memory, energy, and overall brain health.

Additionally, the great thing about Qualia Mind is that it offers a variety of custom options: Neurohacker Collective offers Qualia Mind, Qualia Mind Caffeine Free, Qualia Mind Essentials, and Qualia Focus among other nootropic supplements.

UpWellness Mind & Mood

Product Description
Company: UpWellness
Working Components: The brain supplement reportedly aids your emotional health and stress management using adaptogenic ingredients such as 5-HTP, GABA, Rhodiola Rosea, L-theanine (amino acid), and saffron
Quantity Delivered: 60 capsules
Serving Size: Two capsules
Assurance: 60-days money-back guarantee
Mind & Mood Retails at $57

We’ve already seen many nootropics that aid good cognition, focus, and memory. However, Mind & Mood is a brain health supplement from UpWellness that takes a slightly different direction. It mainly targets emotional well-being, anxiety, and stress. Drs. Joshua and Amanda Levitt created Mind & Mood, making it one of the few formulas on this list made by board-certified medical professionals.

Mind & Mood claims to calm and relax the nervous system if you take it daily. It can vitalize brain chemicals to produce healthy brain cells, provide mental clarity, and avoid cognitive decline.

PureEssence BrainEssence

Product Description
Company: Puressence
Working Components: The nootropic blend consists of high doses of acetyl l-carnitine, Bacopa monnieri extract, and ashwagandha. Apart from these, it also contains smaller amounts of Chinese club moss extract with Huperzine A, Rhodiola Rosea extract, and alpha-lipoic acid (amino acid), among other beneficial ingredients
Quantity Delivered: 30 pills
Serving Size: Two pills
Assurance: 90 days money-back guarantee
BrainEssence Retails at $30

BrainEssence Brain Supplement from PureEssence claims to improve memory recall, boost mental energy and clarity, enhance cognitive performance, and uplift your Mood. In contrast to other supplements, this comes in a tablet, not a capsule.

Though it comes at a steep price, the great thing about PureEssence is that it discloses all ingredients and dosages on the label. This is wonderful because it’s easy to see what’s going into your mouth with every serving of BrainEssence.

Amy Myers MD NeuroLive

Product Description
Company: Amy Myers MD
Working Components: NeuroLive’s patented formula contains a host of good ingredients, including vitamin B6, phosphatidylserine, pruriens seed extract, bacopa monnieri extract, ginkgo Biloba leaf extract, mucuna, and N-Acetyl Tyrosine
Quantity Delivered: 60 capsules
Serving Size: Two capsules
Assurance: 90-days money-back guarantee
NeuroLive Retails at $49.97

Amy Myers MD’s NeuroLive is a nootropic supplement formulated and recommended by physicians. Science-backed and containing seven high-profile micronutrients, NeuroLive makes a compelling argument for why it isn’t among the best products currently available online.

The combination of nutrients provides natural cognitive function support for a healthy brain. The nootropic stacks in this formula support perfect vasculature and healthy blood flow more effectively than anything else available today.

Brain C-13

Product Description
Company: Zenith Labs
Working Components: The Brain C-13 formula targets brain pathways with Rhodiola root extract, DMAE, rosemary leaf, Huperzine A, turmeric, ginkgo leaf, and phosphatidylserine to improve brain health
Quantity Delivered: 90 pills
Serving Size: Three pills
Assurance: 180 days money-back guarantee
Brain C-13 Retails at $49

Brain C-13 is a nootropic supplement by Zenith Labs containing many plant extracts, vitamins, minerals, and herb extracts. Ingredients-wise, the brain supplement is quite comparable to other formulations mentioned in our list here.

Like other dietary supplements manufactured by Zenith Labs, Brain C-13 is also formulated by physicians and doctors while supporting their medical advisory board.

Elm & Rye Nootropics

Product Description
Company: Elm & Rye
Working Components: n every serving of Nootropics, you get an ample dose of alpha GPC, GABA, L-theanine, L-tyrosine, bacopa monnieri, extract phosphatidylserine extract, and B vitamins
Quantity Delivered: 60 pills
Serving Size: Two pills
Assurance: 30-day satisfaction guarantee
Elm & Rye Nootropics Price: $85

At a heavy price tag of $85, Nootropics by Elm & Rye has to be the most expensive brain booster mentioned on our list. Elm & Rye includes ingredients that support improved memory, increased focus, and increased productivity to justify the high price.

If you’re a caffeine nut, Nootropic will give you your daily dose without having to drink your morning coffee. Despite the higher price point, Elm and Rye Nootropics may be the best option for you if you’re looking for an instant kick combined with other proven nootropic effects.

Neuro Energy and Focus

Product Description
Company: Neuro
Working Components: B-Vitamins, Caffeine, L-theanine, and other minerals and flavors
Quantity Delivered: Nine pieces
Serving Size: One gum
Assurance: 100% happiness guarantee
Neuro Price Retails at $21+

Neuro nootropic supplements are among the cheapest brain supplements we have reviewed here. It is the only Nootropic here that’s available in the form of gummies and mints. Neuro sells three kinds of gums and mints: Calm & Clarity, Energy & Focus, and Ideal State. Taking these every day can introduce calmness, energy, or greater focus into your life.

Whether you’re seeking buzzing energy in the morning, optimal Mood and wakefulness in the afternoon, or an overall sense of well-being throughout the day, Neuro could be one of the best nootropic supplements for you.

PureHealth Research Ageless Brain

Product Description
Company: PureHealth
Working Components: As part of the formulation, the brain supplement uses GABA, Huperzine A, B vitamins, and caffeine, among other ingredients, to promote cognitive functions on several levels
Quantity Delivered: 30 capsules
Serving Size: One capsule
Assurance: 365-day money-back guarantee
PureHealth Research Ageless Brain retails at $44

Here is another nootropic on our list called Ageless Brain. But this one is manufactured by the brand PureHealth Research. Created by Dr. Holly Lucille, Ageless Brain by PureHealth Research is a nutritional brain supplement that uses many ingredients to support its nootropic properties.

One capsule of Ageless Brain a day can purportedly reduce anxiety and brain fog, enhance memory and focus, and boost memory and cognitive wellness, among other benefits.

Cymbiotika Golden Mind

Product Description
Company: Cymbiotika
Working Components: Each serving of Golden Mind features ingredients like organic lion’s mane mushroom powder extract, phosphatidylcholine, L-theanine, and Rhodiola Rosea to improve brain function and nervous system
Quantity Delivered: 30-day serving
Serving Size: 14 pumps
Assurance: Not any
Cymbiotika Golden Mind Price: $50

If you’re not fond of popping capsules and pills, here’s an excellent substitute for you!

Cymbiotika’s Golden Mind is a nootropic formula in liquid tincture form instead of the typical capsules or powders.

In addition to reducing brain fog, protecting your brain, and nurturing brain cells, taking Golden Mind every day is said to have other benefits, according to the manufacturer. Aside from the usual ingredients, Golden Mind also incorporates other nootropic stacks that we don’t often find in supplements. These include things like Gotu kola extract, sea buckthorn oil, and a mix of 82 different ocean minerals to give your brain an energy boost like no other.


Product Description
Company: biOptimizers
Working Components: 30 billion CFUs of probiotics, Chinese Herbal Blend, Organic Inulin, Xylooligosaccharide, and others
Quantity Delivered: 60 capsules
Serving Size: Two capsules
Assurance: One-year money-back guarantee
CogniBiotics Retails at $62

CogniBiotics is quite similar to other nootropic formulas and brain pill supplements on this list as it claims to improve brain health, learning, memory, mental clarity, and focus. But unlike any other nootropic on our list, CogniBiotics doesn’t directly target the brain. Instead, it focuses on optimizing digestion to improve your brain health indirectly.

Bacteria in the gut play a vital role in optimal brain function. And while you may not know it, the deteriorating health of your gut flora can lead to impaired cognitive function. The nutrients in the brain pill boost brain function, Mood and even eliminate stress by supporting your gut health.

ProMind Complex

Product Description
Company: NA
Working Components: The main active ingredients in the ProMind Complex include phosphatidylserine, bacopa monnieri, L-glutamine, Huperzine A, Ginkgo Biloba Leaf, and vinpocetine
Quantity Delivered: 30 capsules
Serving Size: One capsule
Assurance: 60-day satisfaction guarantee
ProMind Complex Retails at $69

ProMind Complex is a nootropic formula developed by Carl Henderson. According to Henderson, he has used his decades-worth of experience to formulate the perfect nootropic supplement in the shape of ProMind Complex.

Despite the manufacturer making correct claims about ProMind Complex’s ingredients, it fails to deliver. The list of ingredients is much like any other brain supplement you’ve seen, containing nootropics that are proven to be effective. But despite its high cost, the dosage of active ingredients is surprisingly low in the ProMind Complex.

Oweli Neuro

Product Description
Company: Oweli
Working Components: Huperzine A, bacopa monnieri, phosphatidylserine, B vitamins, inositol, and DMAE
Quantity Delivered: 60 veggie capsules
Serving Size: Two capsules
Assurance: Money back guarantee of 100 days
Oweli Neuro Retails at $30

The unique Nootropic Oweli Neuro delivers a Zen-like focus in a capsule. It is marketed as a product that can promote neuroplasticity and fight age-related cognitive decline, among other things.

Each Neuro serving consists of natural ingredients to promote productivity, focused thinking, and a good mood. The formula can promote brain cell regeneration, boost cognitive function, strengthen the nervous system, and peak mental acuity. For just $30 per bottle, Oweli Neuro is an excellent buy at a low price, providing you with the best value.

Brain Pill

Product Description
Company: Leading Edge Health
Working Components: The nootropic stack has citicoline, vitamin B12, tyrosine, and L-theanine to boost mental function and offer a range of cognitive benefits
Quantity Delivered: 60 pills
Serving Size: Two pills
Assurance: 67 days money-back guarantee
BrainPill Retails at $69.95

According to Brain Pill, it gives you an “unfair advantage.”. Brail pill makes big claims to banish brain fog, combat mental fatigue, enhance memory recall, and improve learning and other cognitive abilities. The marketing team at Brain Pill knows what to say to capture their customer’s attention. However, the Nootropic is priced higher than other similar brain supplements while also containing lower dosages.

Brain Pill boosts cognition with no unwanted side effects and is also recommended by Dr. Dave David for better brain health. While the company claims to use “proper doses” of active ingredients, it does so without disclosing complete dosage information upfront. Brain Pill does not provide precise dosage details for many elements in the formula. That is why the brain supplement lands itself a tier lower than other top-ranked nootropic supplements on our list.


Product Description
Company: AlternaScript
Working Components: Bacopa monnieri with 55% bacosides, GABA, L-Tyrosine, Alpha Lipoic Acid, and caffeine
Quantity Delivered: 32 capsules
Serving Size: One capsule
Assurance: Not any
OptiMind Retails at $30

Assurance: OptiMind is a mental energy-boosting, focus enhancing, and cognitive function supporting supplement priced at $39 per bottle. Approximately 32 capsules are included in each bottle for giving you daily energy, mental clarity, and increased focusing ability.

The critical ingredients of OptiMind are Bacopa monnieri with 55% bacosides. In addition to its powerful cognitive support benefits, bacopa monnieri in OptiMind also works to enhance focus, concentration, and memory.


Product Description
Company: NA
Working Components: N-Acetyl-L-Carnitine, St. John’s Wort, and Phosphatidylserine
Quantity Delivered: 30 capsules
Serving Size: One to two capsules
Assurance: 60 days satisfaction guarantee
MemoSurge Retails at $69

MemoSurge claims to work as the ultimate nootropic supplement in a three-step process. Firstly, it increases neurotransmitter activity in your brain and develops new brain cells. In addition to repairing damaged brain cells, the blend also eliminates brain shrinkage. Last but not least, the formula promotes energy by eliminating insomnia and mental fatigue.

Youthful Brain

Product Description
Company: Vitality Now
Working Components: Bacopa monnieri, vitamin B12, and Huperzine A
Quantity Delivered: 60 pills
Serving Size: Two pills
Assurance: Money back guarantee of 190 days
Youthful Brain Retails at $65

The multiple active ingredients in the nootropic supplement contribute to brain health, mental energy, and cognitive function.

Young Brain contains similar ingredients to other leading nootropic formulas we’ve reviewed. That is why we have lowered its ranking on this list of the best-rated nootropic supplements due to its lower dosages and higher price per bottle.

ReMind Solution

Product Description
Company: NA
Working Components: The nootropic stack has various cognitive enhancers like N-acetyl L-carnitine, Huperzine A, Ginkgo Biloba, Bacopa Monnieri, and L-glutamine
Quantity Delivered: 30 pills
Serving Size: One pill
Assurance: 60 days money-back guarantee
ReMind Solution Price: $69

ReMind Solution uses clinically proven ingredients to combat anxiety, depression, and cognitive and focus issues, among other mental problems. You get only a 30 days’ supply of nootropics for $69, which brings us to ReMind’s main drawback. The price of the brain pill is too high for the little value it provides.

Memo Defend

Product Description
Company: NA
Working Components: The 620mg proprietary blend of Memo Defend contains vitamin B12, garlic bulb, Hawthorn leaf, and olive leaf, which don’t have any noteworthy nootropic properties, according to current research
Quantity Delivered: 60 pills
Serving Size: Two pills
Assurance: 60 days money-back guarantee
Memo Defend Price: $69

Manufactured by Thomas Taylor, Memo Defend supplements natural nootropic nutrients to support optimal brain functioning. The main reason Memo Defend sits at the lower end of this list is that its ingredients, dosages, or lab testing information are not provided, as they are with other high-ranking supplements.

Memory Hack

Product Description
Company: Nutrition Hack
Working Components: It contains St. John’s Wort, Ginkgo Biloba, L-Theanine, Choline, and many to boost mental processing speed, enhance blood flow and optimize brain health
Quantity Delivered: 60 capsules
Serving Size: Two capsules
Assurance: 60-day money-back guarantee
Memory Hack Price: $69

Nutrition Hacks manufacture this nutritional supplement. Like most other low-rated nootropics, Memory Hack is priced high, but it fails to provide high-quality ingredients or potent dosages to make up for the high price.

Memory Hack’s marketed benefits are the most significant issue, not its high price. It interacts with the nervous system to release brain chemicals and boost mental performance.

Brain Supplements and Science

By now, you must be tired of hearing how truly unique nootropics are and how they boost brainpower. But manufacturers’ claims aside, you can’t help but wonder whether nootropics work or if they are just a scam?

Nootropics were unknown until a few years ago. But today, there’s an ample amount of research supporting nootropic formulas and their effectiveness. Clinical trials have proven that the nootropic ingredients in popular brain supplements are effective following extensive research.

Bacopa Monnieri

For centuries, Bacopa monnieri, a popular nootropic supplement, was widely used in Chinese medicine to cure numerous ailments. During a 2001 study, 300mg of Bacopa monnieri was given over 12 weeks. The research showed that nootropics “may improve higher-order cognitive processes,” especially memory recall and learning.

Another 2008 study showed that a 300mg dose of Bacopa monnieri enhanced older adults’ attention, memory, and mental processing speed. As per research, 300mg to 600mg a day is the best dosage for Bacopa monnieri.

Ginkgo Biloba

Traditional Chinese medicine has long used Ginkgo Biloba as an herbal extract. Scientists in a study conducted in 2001 gave participants Ginkgo Biloba and vinpocetine (another nootropic ingredient) for 14 days and evaluated their results. In the ginkgo Biloba group, the response times and memory were faster than in the placebo group.


Coffee has always had a bad reputation for its adverse effects. But many people use L-theanine to offset these unwanted effects. It is one of the natural amino acids that enhance brain activity. However, there is more to it than just that. A study found that taking 50mg of L-theanine, the same amount found in two cups of coffee, increased alpha brain wave activity and creativity without decreasing stimulant effects.

Huperzine A

Huperzine A, an extensively studied one, is a popular nootropic ingredient. In a 1999 study, researchers in China observed significant improvements in cognitive function, memory, and symptoms of Alzheimer’s Disease in participants who took Huperzine A compared to those who took a placebo.

Lion’s Mane Mushroom

Lion’s mane mushroom is a dietary supplement that has been used in traditional Chinese medicine for centuries to treat a variety of conditions, including memory impairment. Some human studies have also shown that lion’s mane mushroom may improve cognitive performance, brain performance, and brain function. It can also support the nerve growth factor.

There is limited research on the effects of the lion’s mane mushroom on memory function. However, preliminary studies suggest that it may have cognitive benefits, such as improving short-term memory and learning ability. More research is needed to confirm these findings.

In general, the top nootropic supplements today contain ingredients that contribute to optimal cognitive functioning, focus, memory, and more. Make sure the ingredients and dosage are backed by science to get the most out of your nootropic formula.

How We Ranked The Best Nootropics

The supplement market is flooded with nootropics, and supplement manufacturers all make similar claims – some nootropics fulfill those promises. Based on reviews of lab reports, contacting the manufacturing companies, consultations with our team members, and undertaking other due diligence, here’s how we select which nootropics make it to our list:

Active Ingredients That Work

In several studies, certain ingredients have been shown to support healthy brain function. That is why our top-ranked nootropics feature ingredients and dosages backed by science.

Scientifically Developed and Medically Approved

Medical doctors (MDs) and naturopaths (NDs) create a handful of nootropic supplements. Others are approved by their in-house medical advisory board. A nootropic with more professional certifications received a higher ranking from our team for our list.

Authentic Customer Reviews

Even if you take the best nootropic supplement out there, it may not work for everyone. Therefore, we compared the subjective experiences of our editorial team with those of actual customers. This information has been considered in each product’s rating.

Transparency of Marketed Benefits

Companies selling nootropic supplements tend to exaggerate the benefits of their products to attract customers. In their marketing materials, they claim their formulas will speed up your brain and improve your memory and focus, in addition to boosting your cognition. Regarding the advertised effectiveness of their nootropics, the best companies are honest and transparent.

Potent Dosages

Despite being composed of the right ingredients, many nootropic supplements contain the wrong dosages. There are formulas with dozens of active ingredients, but the dosages are insufficient to produce any noticeable effect on the body.

Proprietary Blends and Patented Formulas

Proprietary blends seem to have become a mainstay for many supplements. There is a growing trend of hiding weak dosages. In some cases, companies hide stimulants like caffeine behind the proprietary blends label. A supplement might appear to soar your cognitive abilities – when you’re ingesting a 280mg dose of caffeine bundled into a 350mg formula.

Research & Clinical Trials

There is a high cost to conducting clinical trials, and they take a lot of time. Because of this, few companies invest in clinical trials for nootropic supplements. The recent surge in the popularity of nootropics has led some companies to conduct clinical trials and publish research in peer-reviewed journals, giving them an edge over their competitors.

Price Vs. Quality

Some people can spend $200 a month on nootropic supplements, whereas others can’t afford to pay more than $20 a month on supplements. For us, the best nootropic supplements provide good value for money. No matter how much you want to spend on brain supplements to support your brain health, we listed a range of options to choose from.

Nootropic Supplementation FAQs

Q: What are nootropics?

A: Nootropics are mostly dietary supplements or smart drugs that have a profound ability to enhance brain functioning.

Q: How do nootropics affect the brain?

A: Different nootropics act differently on the brain. Some are targeted to improve overall cognition, focusing on memory recall. Others work by enhancing executive functions and strengthening neural pathways.

Q: Who can take nootropic supplements?

A: As smart drugs are made to boost memory and mental function, they are generally meant for individuals with a greater need for optimal brain function. These may include athletes, entrepreneurs, students, older adults, and pretty much anyone who needs an extra boost to manage their busy schedule.

Q: What benefits do nootropics offer?

A: You can use nootropic supplements to see improvement in cognitive functioning, brainpower, and better productivity in day-to-day tasks. But you can also get nootropics for specific issues like poor memory or brain fog.

Q: Are nootropic supplements vegan?

A: Mainly being herbal and plant-based, the active ingredients in nootropics are usually vegan. However, some manufacturers package their ingredients in gelatin capsules, animal-derived products.

Q: Do nootropics have an addictive quality to them?

A: No, nootropics or smart drugs do not possess any addictive traits by their nature.

Q: What is the best way to take nootropics and smart drugs?

A: Smart drugs or nootropics can be taken with plain water. You can mix powdered dietary supplements into drinks to make them more enjoyable. But for best use, follow the instructions mentioned on each nootropic supplement.

Q: What’s the best time to take nootropic supplements?

A: Just like other dietary supplements, you can take smart drugs anytime during the day when it suits you. Most consumers prefer to take their dose in the morning or afternoon. For nootropics that contain stimulants like caffeine, it’s not advised to take them late at night, as they could make it more difficult to sleep.

Q: Where can I purchase nootropics?

A: You can buy smart drugs both online and offline. Most nootropics supplements are readily available at leading stores like Amazon, Walmart, CVS, and more.

The Top 33 Best Nootropics of 2022 Conclusion

Boosting brainpower has never been easier!

Today’s nootropic supplements and smart drugs have great potential to protect and improve healthy brain function. Enhancing cognitive abilities, these dietary supplements make you more efficient and effective at work and home.

Different nootropics leave different effects on people. Knowing your individual needs allows you to choose a supplement that suits your requirements. Therefore, take advantage of our guide on the best 33 nootropic brain boosters and cognitive enhancers you can get your hands on in 2022.

With the right nootropic supplement, you’re only steps away from boosting your memory, executive functioning, and so a whole lot more.

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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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